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17-AAG hydrochloride

CAS No. 911710-03-7

17-AAG hydrochloride( Tanespimycin Hydrochloride | NSC 330507 Hydrochloride | CP 127374 Hydrochloride )

Catalog No. M16543 CAS No. 911710-03-7

A potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    17-AAG hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays.
  • Description
    A potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays; induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells; causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor; inhibits prostate cancer xenografts growth in mice.Skin Cancer Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Tanespimycin Hydrochloride | NSC 330507 Hydrochloride | CP 127374 Hydrochloride
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    Cancer
  • Indication
    Skin Cancer

Chemical Information

  • CAS Number
    911710-03-7
  • Formula Weight
    622.1494
  • Molecular Formula
    C31H44ClN3O8
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC.Cl
  • Chemical Name
    Geldanamycin, 17-demethoxy-17-(2-propenylamino)-, monohydrochloride (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kamal A, et al. Nature. 2003 Sep 25;425(6956):407-10. 2. Solit DB, et al. Clin Cancer Res. 2002 May;8(5):986-93. 3. Nimmanapalli R, et al.Cancer Res. 2001 Mar 1;61(5):1799-804.
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